Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA
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چکیده
منابع مشابه
Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA
Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely, the antisense approach that recruits RNase H to cleave target RNA and the RNAi approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. We compare the silencing of the asthma susceptibility gene ADAM33 in MRC-5 lung fibroblasts using ...
متن کاملLocked Nucleic Acid gapmers and conjugates induce potent silencing of ADAM33, an asthma-associated metalloprotease with nuclear-localized mRNA
Two mechanisms dominate the clinical pipeline for oligonucleotide-based gene silencing, namely the antisense approach that recruits RNase H to cleave target RNA and the RNA interference (RNAi) approach that recruits the RISC complex to cleave target RNA. Multiple chemical designs can be used to elicit each pathway. We now compare the silencing of the asthma susceptibility gene ADAM33 in MRC-5 l...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2017
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2017.06.012